Study axonal degeneration of 120 parallel axons

Dr. Margaret Magdesian (Montreal Neurological Institute at McGill University, Canada) while studying axonal degeneration


“With Ananda microfluidic devices, we were able to simultaneously injure 120 parallel axons and follow the regeneration process in one dish. This significantly increased reproducibility and the amount of results obtained per culture. With a regular cell culture dish it would have taken at least 30 dishes and much more microscope time because all processes were entangled and with different sizes.”



Regular neuronal cell culture in a petri dish without Ananda Devices' neuronal microfluidic device

Regular culture plate

Neuronal cell culture with Ananda Devices' neuronal microfluidic device

With Ananda Devices
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Picture of neurons'organization in the brain.

In the brain


Reproducibility of axonal damage

Margaret was investigating axonal resistance to injury and needed uniform single axons to produce precise cause damage and evaluate regeneration at the single cell level.

Tracking cell response to specific stimuli over time

Dr. Margaret Magdesian needed a way to ensure reproducibility of the specific impact of injury on cells, and also to trace and record the behavior of cells in response to specific stimuli over time.

For more details please refer to: Magdesian et al., Biophys J. 2012 and Magdesian et al., J. Neuroscience 2016